Antiepileptic drug treatment is effective. There was a low frequency of seizures in patients with generalized tonic-clonic seizures. Precipitating factors were found in relation to 31% of seizures in patients with remote symptomatic or cryptogenic epilepsy, and for 51% of seizures in patients with idiopathic epilepsy. The frequency of seizures was significantly lower during treatment. Without treatment 97 seizures manifested during 90.5 years without treatment (1.07 seizures/year), during treatment with carbamazepine or valproate 49 seizures occurred within 224 years (0.2 seizures/year). The total number of seizures in all patients was 146.
Retrospective analysis of data from 34 patients (mean age at seizure onset 19 years mean duration of follow-up 9.2 years) suffering from epilepsy of either cryptogenic or remote symptomatic (n = 19), or idiopathic (n = 15) etiology. The aim of the study was to evaluate the influence of precipitating factors and therapy on the outcome of epilepsy with generalized tonic-clonic seizures. Precipitating factors and therapeutic outcome in epilepsy with generalized tonic-clonic seizures.īauer, J Saher, M S Burr, W Elger, C E longer (called the post-ictal state) Loss of memory (amnesia) about the seizure episode Headache Weakness of. tonic-clonic seizures have vision, taste, smell, or sensory changes, hallucinations, or dizziness before the seizure.
We present a rare case of tonic-clonic seizures in a patient receiving Oxaliplatin in the absence of PRES. One case report has been described in the literature. Oxaliplatin-induced seizures rarely occur in the absence of PRES. After 5 cycles of FOLFIRI, the patient did not develop any seizures, making Oxaliplatin the most likely culprit for his seizures. His chemotherapy regimen was switched to Folinic acid, Fluorouracil, and Irinotecan (FOLFIRI. The patient was rechallenged with FOLFOX but he had tonic-clonic seizures for the second time. EEG and MRI of the brain showed no acute abnormality. Laboratory workup was within normal limits. During the third cycle of FOLFOX, the patient developed tonic-clonic seizures. Adjuvant chemotherapy was started with Folinic acid, Fluorouracil, and Oxaliplatin (FOLFOX. Appendectomy was done and pathology showed mixed adenoneuroendocrine carcinoma. CT scan of the abdomen showed acute appendicitis. A 50-year-old male patient presented with severe abdominal pain. A rare side effect is seizures which are usually associated with posterior reversible leukoencephalopathy syndrome (PRES. Common side effects are peripheral neuropathy, hematological toxicity, and allergic reactions. Continued abuse of our services will cause your IP address to be blocked indefinitely.Oxaliplatin-Induced Tonic-Clonic Seizuresĭirectory of Open Access Journals (Sweden)įull Text Available Oxaliplatin is a common chemotherapy drug used for colon and gastric cancers. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.
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